WebMetoprolol (minipress, norm, noroverell) is a beta-blocker used to treat angina, high blood pressure (also known as hypertension) and heart failure leading to cancer of the lining of the gastrointestinal tract (crohn tumor). With oral metoprolol succinate extended-release (ER) tablets, peak concentrations are reached in about seven hours following a single dose. May interfere slightly with laboratory cholesterol results. taking metoprolol 25mg suc er. NSAIDs decrease prostaglandin synthesis. Minimally clinically significant. Side effects are similar for both metoprolol succinate and metoprolol tartrate because they both contain the same active drug, metoprolol. This tool may not cover all possible drug interactions. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. The blood pressure-lowering effects of metoprolol succinate ER tablets persist for about 24 hours following a single dose. Note that this list is not all-inclusive and includes only common medications that may interact with metoprolol succinate. This is not a complete list of side effects and others may occur. //-->,